這周讀了一篇用計算模式模擬BG-thalamocoritcal circuit來探討Parkinson’s disease的病人產生bradykinesia的機轉以及Deep brain stimulation的作用機轉的paper (Rachel Moroney, Ciska Heida, and Jan Geelen, “Increased bradykinesia in Parkinson’s disease with increased movement complexity: elbow flexion–extension movements,”
Journal of Computational Neuroscience 25, no. 3 (July 10, 2008): 501-519.
http://www.springerlink.com/content/l671l99081v5645j/fulltext.html)
覺得其中用的計算模式還滿有趣的,就用matlab實作了一下

(paper中使用的circuit模型,包含direct/indirect和hyperdirect pathyway)